Germinal technology

The origin and development of soft laser hair growth technology

It is undeniable that hair loss has received increasing attention, androgenetic alopecia (AGA) is the most common form of hair loss, its prevalence is

increasing, the United States Food and Drug Administration (FDA) has now approved 3 ways to control AGA: finasteride, minoxidil, low-energy laser (LLLT).

The first two are drugs, but it has been found that many users have adverse reactions after taking the drugs, and their safety and effectiveness are controversial. The effect of LLLT was significant, and no side effects were found throughout.

In fact, LLLT has long been studied and applied to the protection of various clinical symptoms. Based on the principle of biological photobiomodulation, LLLT can effectively relieve rheumatoid arthritis, osteoarthritis, tendinopathy, and promote skin wound regeneration, wound healing, and hair regeneration. The purpose of this article is only to explain the effect of LLLT on hair loss control. effectiveness.

It is undeniable that hair loss has received increasing attention, androgenetic alopecia (AGA) is the most common form of hair loss, its prevalence is increasing, the United States Food and Drug Administration (FDA) has now approved 3 ways to control AGA: finasteride, minoxidil, low-energy laser (LLLT).

The first two are drugs, but it has been found that many users have adverse reactions after taking the drugs, and their safety and effectiveness are controversial. The effect of LLLT was significant, and no side effects were found throughout.

In fact, LLLT has long been studied and applied to the protection of various clinical symptoms. Based on the principle of biological photobiomodulation, LLLT can effectively relieve rheumatoid arthritis, osteoarthritis, tendinopathy, and promote skin wound regeneration, wound healing, and hair regeneration. The purpose of this article is only to explain the effect of LLLT on hair loss control. effectiveness.

Since then, experiments on LLLT have been silent for many years, until in recent years, with the increase in the number of people with hair loss, LLLT has attracted a lot of attention again.

In 2003, the research subjects were transferred from mice to subjects with alopecia areata, and Japanese scientist Yamazaki M. organized 15 subjects with alopecia areata (6 males and 9 females) to receive an infrared laser with a laser device called Super Lizer™. Irradiation experiments. Their scalps received 3 minutes of irradiation once a week.

It was found that 47% of people who received infrared laser irradiation experienced hair growth 1.6 months earlier on the irradiated skin than on the non-irradiated skin. After 1 year of irradiation, all scalp symptoms disappeared. Hair density, length and diameter of hair shafts of diseased skin after irradiation and non-diseased skin converged. This confirms that LLLT accelerates the process of hair regrowth in subjects with alopecia areata.

That same year, American scientist Satino tested 28 male and 7 female AGA subjects for hair growth and tensile strength under LLLT. Each patient used the laser comb for 5-10 minutes every other day for 6 months.

The results showed a dramatic improvement in the tensile strength of the hair on the top of the head in males and in the temporal regions (both sides of the forehead) in females. Significant improvements in hair count were achieved in both men and women (55% of women and 74% of men had significant hair growth in the temporal region; 65% of women and 100% of men had significant hair growth on the crown of the head).

In 2013, American scientist Lanzafame organized an experiment on a laser helmet, which contained a laser diode (LD) and a light-emitting diode (LED). The experiment lasted 16 weeks, every other day, and concluded that all male AGA subjects achieved 35% hair growth.

In addition, LLLT has been shown to modulate inflammatory processes and enhance immunity, thereby stimulating hair regrowth. Scientist Wike’s research has shown that laser combing significantly increases the number of anagen hair follicles in the skin and significantly reduces inflammatory penetration.

Since 1967, the efficacy of LLLT in controlling hair loss has been attracting attention, and many people have tried to convert the results of scientific research into home hair growth equipment to increase the frequency and effect of use.

In the 1970s, the helium-neon laser instrument was introduced. The 632.8nm helium-neon laser proved to have deep penetration into the skin, which can improve skin microcirculation, accelerate metabolism, promote the proliferation of epithelial cells and fibroblasts, and promote hair growth. It is one of the options for controlling alopecia areata.

However, the cost of helium-neon laser hair growth equipment is too high, and it cannot be used in ordinary households. It can only be used as a large-scale medical equipment. Since the beginning of the 21st century, lower-cost semiconductor materials have laid a solid foundation for LLLT home equipment, such as light-emitting diodes (LEDs) and laser diodes (LDs), which both emit wavelengths similar to He-Ne lasers and achieve similar hair growth effects.

First generation home LLLT equipment

Laser hair growth comb

Combing hair is considered a way to promote blood flow to the scalp, LLLT combined with a comb is an important milestone in the transformation of LLLT medical hair growth equipment into a household device.
  • Advantage

    FDA certification: The first to invent LLLT home equipment, and the first to obtain the US Food and Drug Administration certification.

    Clinical trials: 90% of subjects with hair loss found it to be effective, unisex.

    Patented tooth separation technology: It is easier to open the hair, let the laser directly hit the skin and penetrate deep into the scalp.

    • disadvantage

      Insufficient number of lamps: only 7-12, the effect is slow and the effective time is long.

      Activity limitation: When using it, you need to hold it for 15 minutes to comb your hair, which is easy to get tired and the movement of your hands is limited.

      Poor service: Because the equipment is imported and the service provider is in the United States, the merchant does not promise the effect, nor does it support returns or exchanges. In addition, there is a lack of value-added services and no interaction between doctors and patients.

      • summary:

        Although the laser hair growth comb has realized the conversion from large health care equipment to small household health care equipment, it still has many shortcomings and is not suitable for the fast-paced life of modern people, so it is defined as the first generation of LLLT household equipment.

First generation home LLLT equipment

laser hair growth helmet

Laser hair growth helmet is a major breakthrough of LLLT home equipment, freeing hands, allowing users to accept laser without affecting their daily life.
  • Advantage

    FDA clearance and clinical trials: Same as first generation device.

    Free your hands: You can read books, watch TV, work, etc. while using the helmet.

    Full scalp coverage: In the form of a helmet, the entire head can be covered better, and the laser can completely irradiate most of the hair loss parts.

    Built-in speaker: voice reminder for each use process.

    • disadvantage

      Excessive weight: A 650-gram helmet needs to be worn for 20 minutes each time, which can easily cause headaches.

      Poor service: Same as 1st generation device.

      • summary:

        The epoch-making significance of the laser hair growth helmet is to free hands and achieve full scalp coverage. Although the advantages of the equipment are remarkable, the helmet technology is only 4 years old and still immature, and its clinical application technology is also constantly developing.

Analysis of the development trend of laser hair growth products

Compared with drugs, hair salons, and hair transplants, home laser hair growth equipment has no side effects, can greatly improve time efficiency, and has a significant effect. Since 1967, LLLT has transitioned from large medical equipment to small household equipment, and in the process of continuous upgrading of household equipment, there are several rules as follows:

  • Incrementing the number of laser lights

    Facts have proved that increasing the density of the laser light and the light energy per square centimeter can improve the effect. It can be seen from the iterative process of the equipment that from the beginning of 7, 12 to 21 and 80 lights, the number of lights and the hair growth effect are proportional within a certain range.

  • The wavelength is concentrated in 630~680nm

    In all experiments on LLLT since 1967, whether it is helium-neon laser, LED or LD, the laser hair growth effect of this band is more obvious.

  • LD effect is more obvious

    In the same wavelength band, the laser diode (LD) has a more obvious hair growth effect than the light emitting diode (LED), because the former has a stronger penetrating power to the scalp and is easier to promote the blood circulation of the scalp and the hair growth effect. LD laser technology, deactivated LED lights.

  • Helmet replaces comb

    Freeing your hands is the key to upgrading household equipment. Just imagine that you can grow your hair while doing yoga, watching TV, or reading. It must be an epoch-making innovation.

  • In fact, it is far from enough to do the above points. Regarding LLLT home hair growth equipment, there is still a lot of room for future development. You can try to make breakthroughs from the following points:

     

    • adaptive energy

      All manufacturers ignore one point, the output power of the laser decreases with increasing temperature, so the energy provided by the device to the scalp is inconsistent in different seasons and temperature environments. If the helmet can adapt to the environment and adjust the light energy to ensure that the scalp receives a balanced growth energy every time, the hair growth effect must be a leap and improvement.

    • more lights

      The denser LD laser across the entire scalp ensures that the scalp receives energy from all directions.

    • custom lighting

      Each user has different hair loss parts and degrees. If the scalp can be irradiated in different areas and concentrated energy on the scalp parts with severe hair loss, the hair growth efficiency will be greatly improved.

    • Helmet is lighter

      The 650-gram helmet will constantly put pressure on the scalp on the head, which is easy to cause headaches.

    • Online APP

      The Internet of Everything is the trend of the times, and the sale of equipment is only the beginning of the service. The important thing is to control the chronic disease of hair loss through long-term interactive services, such as personalized light plans, light reminders, hair loss grade

working principle

Low-energy laser therapy (LLLT), a safe and effective treatment for androgenetic alopecia (AGA), i Blackmi uses smart laser LLLT therapy, its 650-nanometer 5-milliwatt low-energy laser that penetrates the scalp The surface layer 3-5 mm directly reaches the hair follicle, and undergoes a photolysis reaction with the respiratory chain target C oxidase in the mitochondria of the hair follicle cell, thereby releasing more NO (nitric oxide), ROS (reactive oxygen species) and ATP (adenosine triphosphate, energy ), to accelerate the metabolism of hair follicles; at the same time, the thermal effect of the laser will accelerate the blood flow rate of the tissues around the hair follicles, NO (nitric oxide) will also play a role in vasodilation, and the endothelial growth factor produced by laser stimulation promotes new capillaries, Provide more nutrients to hair follicles. Under the action of the above-mentioned multiple mechanisms, the shrinking hair follicles are stimulated to regenerate, thereby promoting hair growth.
i Heimi Intelligent Laser Hair Growth System has a number of patented technologies such as original laser matrix, automatic energy stabilization, precise irradiation of intelligent zones, real-time detection of scalp health, remote guidance of experts, and personalized treatment. The effective rate is over 89%.

Function

Promote nutrient absorption, accelerate tissue metabolism

Low-energy lasers can alter the nature of oxidation in cells, speed up electron transfer, regulate the expression of genes that control THE production and repair of DNA, and increase the activity of adenosine triphosphate (ATP) in the subskin tissue, which is the main agent of material transfer between cells.  The effect is to increase blood circulation, increase protein and DNA synthesis, stimulate the activity of fiber cells, ATP production, etc., so accelerate the tissue metabolism to send more nutrients to the hair follicle, to prevent shedding, stop shedding and hair. 

Effectively kill hair pathogenic bacteria, improve hair follicle activity

Soft laser can kill fungi and mites hidden in the deep hair follicle.  The heat effect of laser through the neurohumoral response, eliminate the pathological process of inflammation, the original destroyed physiological balance state is restored, improve the local and systemic resistance to disease, activate the immune cell function, strengthen the phagocytosis of white blood cells and reticuloendothelial cells, to achieve the purpose of anti-inflammatory bacteriostasis. 

Irradiation can make the hair follicle open, improve the vitality of hair mother cells and stem cells, accelerate cell fission conducive to drug absorption.

The heating effect of the inferior smooth make skin temperature increases, the sympathetic nerve ability reduce, make the vascular active substances release, vasodilation, blood flow is accelerated, improve blood circulation, enhance the nutrition, active tissue metabolism, improve the cell oxygen supply, improve the supply of blood oxygen of the lesion area, strengthen the ability of cell regeneration, control the development of inflammation and make it localized, accelerated the lesion repair. 

It activates the activity of biological macromolecules. So that the molecules of the organism can be excited and in a high vibrational strong state.

This will activate the activity of nucleic acid protein and other biological size molecules, so as to play the role of biological macromolecules in regulating the body’s metabolism, immunity and other activities, conducive to the recovery and balance of function, to achieve the purpose of disease prevention and treatment. 

Theoretical Basis

A. Foreign experiments:  <>, Volume 5, Number 2,  2003 Hair Regrowth and Increased Hair Tensile StrengthUsing the HairMax LaserComb forLow-Level Laser TherapyAuthor:   JOHN l. SATINO.  Clinical results showed that the average amount of hair increased by 40% after 4 months of low-energy laser irradiation on the scalp.  Within 6 months, the significant response rate was 93.5%, with an average of 165 hairs per square inch, which is a very high clinical response rate. 

B. Domestic experiments: Chinese Journal of Lasers 2005, Study of Low Energy Laser on hair loss and its interaction Mechanism state Key Laboratory of Laser Technology, Huazhong University of Science and Technology state Key Laboratory of Laser Technology  Conclusion: The laser diode (LD) with a wavelength of 650-670 nm and 5MW is used to design an instrument suitable for head irradiation. It is found that the laser irradiation method can achieve a certain effect through the practical effect of nearly one year. 

Clinical Manifestations

1. In the scalp tissue after soft laser irradiation, the blood flow of the scalp increases by 54%, the intake of oxygen increases, and the metabolism is accelerated;

2. The activities of cytochrome oxidase and heparinase related to hair growth are increased, and the growth intensity of nerve growth factor NGF is increased by 5 times, which makes the hair follicles rapidly transition to the growth phase;

3. Molecular biology studies have also confirmed that soft laser enhances the genome expression of many proteases related to hair growth in scalp tissue; LLLT low-energy soft laser cannot change the gene sequence, but can make the genome specific expression related to hair growth. , to promote hair growth.

Conclusion: It is confirmed from the level of molecular biology that the effect of soft laser hair growth is exact and has a physiological basis.